The Ashley lab is focused on the application of genomics to medicine. Specifically, we develop methods for the interpretation of whole genome sequencing data to improve diagnosis of genetic disease and to personalize the practice of medicine. The group includes grad students, post docs, MDs and genetic counselors. We also lead the Stanford Center for Inherited Cardiovascular Disease.
We love network biology. We study diseased hearts from Stanford heart transplants and use RNA sequencing and other tools to derive gene networks and link communities in an attempt to better understand biology. Half of the lab is wet bench so we can easily take advantage of cell systems, transgenic models and microsurgical models of disease to chase down targets and prove causality of our favorite gene targets. Therapeutic development is a near term goal and several of our discoveries are the focus of patents or are being actively pursued by pharmaceutical and biotechnology partners.