The Ashley lab is focused on understanding myocardial adaptation, the process by which the heart adapts to exercise or disease stress. Ultimately, we are systems biologists, driven by a desire for integration. We love network biology and although many of our questions can be answered through computational means, we readily turn to the bench to define causality in the biology of key genes and signaling systems. A major part of our effort is in understanding human genetic variation. With Stanford collaborators, we are developing methods for the clinical application of whole genome sequencing. In addition, we lead the Stanford Center for Inherited Cardiovascular Disease focusing principally on cardiomyopathy and inherited arrhythmia syndromes. Another major interest is the apelin-APJ signaling system. We were among the first to describe the significance of this G-protein coupled receptor system for heart failure and cardiovascular disease. Our overall goal is translation and we are constantly engaged in efforts to move our discoveries from the bench to the clinic.

---

Recent NEWS